Metabolic Studies
MOTS-c
Mitochondrial-derived peptide — metabolic research.
Specifications
- Formula
- C81H132N24O22S2
- Molecular Weight
- 1863.15 g/mol
- Storage
- Store lyophilized at -20°C
- Form
- Lyophilized powder
Description
ERM-142 is a 16-amino-acid mitochondrial peptide investigated in metabolic regulation and insulin sensitivity studies.
Compound Guide
What is MOTS-c?
Targeted Energy & Metabolic Support
MOTS-c is a mitochondrial-derived peptide — encoded not in nuclear DNA but within the mitochondrial genome itself, in the part of the cell responsible for energy production. Research examines it as a signaling molecule between the mitochondria and the rest of the cell, with endpoints centered on metabolic efficiency, energy availability, and fatigue resistance.
Areas of Research Interest
Summarized from published research findings. Not medical guidance or prescribing information.
Cellular Energy
Studied for how efficiently cells create, use, and manage energy at the mitochondrial level.
Metabolic Support
Examined for metabolic efficiency and insulin-sensitivity regulation in metabolic models.
Exercise Endurance
Endurance capacity, exercise tolerance, and age-related physical function are recurring endpoints.
Substrate Access
Research explores improved access to stored fat as an energy substrate during exertion.
Healthy Aging
Recognized in the literature for metabolic resilience measures across the aging curve.
Stress Response
Studied for how cells respond to oxidative stress and maintain mitochondrial function under load.
Reconstitution
- 10 mg vial + 1 mL bacteriostatic water = 10 mg/mL
- 40 mg vial + 4 mL bacteriostatic water = 10 mg/mL
- Both options produce the same 10 mg/mL concentration, so unit counts stay identical
- At 10 mg/mL, 10 units on a U-100 syringe = 1 mg
Suggested research protocol
- Route studied: subcutaneous, rotating administration sites.
- Frequency: 3 administrations per week — commonly Monday, Wednesday, Friday.
- Timing: morning, often in a fasted window.
- Cycle: 12-week blocks with weekly amounts escalating every 4 weeks.
- Protocols are highly individualized; every-other-day designs are also common.
Dosing Reference
| Weeks | Per dose (3× weekly) | U-100 units @ 10 mg/mL |
|---|---|---|
| Weeks 1–4 | 3.33 mg (10 mg/wk) | 33 units |
| Weeks 5–8 | 4 mg (12 mg/wk) | 40 units |
| Weeks 9–12 | 5 mg (15 mg/wk) | 50 units |
Handling & Notes
- Every-other-day administration is preferred in many designs and can be alternated with NAD+.
- Refrigerate after reconstitution and use within 30 days.
- Swirl gently rather than shaking; discard if cloudy or particulate is present.
Stack Up
Compounds studied alongside MOTS-c
This guide is provided for informational and research reference only. MOTS-c is intended for laboratory research use exclusively and is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary consumption.