Recovery & Repair Studies
TB-500
Thymosin Beta-4 fragment — recovery & repair research.
Specifications
- Formula
- C50H69N13O10
- Molecular Weight
- 988.18 g/mol
- Storage
- Store at 2-8°C / 36-46°F
- Form
- Lyophilized Powder
Description
A synthetic peptide studied in research on muscle tissue, recovery, and performance biomarkers.
Compound Guide
What is TB-500?
Cell Migration & Structural Recovery
TB-500 is the synthetic form of the active region of Thymosin Beta-4, a naturally occurring peptide present in nearly all human cells. Its central mechanism in research is actin regulation — the cytoskeletal protein that governs cell migration, meaning repair cells can travel to damaged tissue more efficiently.
Areas of Research Interest
Summarized from published research findings. Not medical guidance or prescribing information.
Actin Upregulation
Promotes cell migration toward injury sites, the mechanistic basis for most TB-500 research.
Vascularization
Studied for new capillary formation in poorly perfused connective tissue.
Flexibility Endpoints
Range-of-motion and scar-tissue measures are common in TB-500 protocols.
Inflammatory Modulation
Examined for downregulation of inflammatory signaling in repair models.
Systemic Distribution
Low molecular weight allows broad tissue distribution rather than local-only action.
Long Dosing Interval
Extended half-life permits twice-weekly rather than daily administration in most designs.
Reconstitution
- 5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL
- 10 mg vial + 5 mL bacteriostatic water = 2.0 mg/mL
- At 2.5 mg/mL, 40 units on a U-100 syringe = 1 mg
Suggested research protocol
- Route studied: subcutaneous, site rotation recommended.
- Loading phase: higher twice-weekly dosing for 4–6 weeks.
- Maintenance phase: reduced weekly dosing thereafter.
- Refrigerate reconstituted vials; use within 30 days.
Dosing Reference
| Phase | Amount | Frequency |
|---|---|---|
| Loading (wk 1–6) | 2–2.5 mg | Twice weekly |
| Maintenance | 2 mg | Once weekly |
| Taper | 1 mg | Every 10–14 days |
Handling & Notes
- Effects in the literature accumulate over weeks rather than days — short blocks are uninformative.
- Frequently studied alongside BPC-157 rather than in isolation.
- Do not freeze reconstituted solution.
Stack Up
Compounds studied alongside TB-500
This guide is provided for informational and research reference only. TB-500 is intended for laboratory research use exclusively and is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary consumption.