Cognitive & Sleep Studies
Semax
Nootropic heptapeptide — cognitive research.
Specifications
- Formula
- C12H22N2O3
- Molecular Weight
- 242.32 g/mol
- Storage
- Store at room temperature, dry
- Form
- Lyophilized Powder
Description
A research compound studied for neuroplasticity, cognition, and memory-related biomarkers.
Compound Guide
What is Semax?
Cognitive Clarity & Neuroprotection
Semax is a synthetic analog of a fragment of adrenocorticotropic hormone (ACTH 4-10), modified with a proline-glycine-proline tail that resists enzymatic breakdown. Research centers on BDNF expression and modulation of dopaminergic and serotonergic signaling — without the ACTH parent molecule's hormonal activity.
Areas of Research Interest
Summarized from published research findings. Not medical guidance or prescribing information.
BDNF Expression
Studied for upregulation of brain-derived neurotrophic factor, central to neuroplasticity research.
Attention Endpoints
Focus, working memory, and task-persistence measures are common in Semax studies.
Neuroprotection
Investigated in ischemic and oxidative-stress models of neuronal injury.
Non-Stimulant Profile
Unlike classical stimulants, it does not produce a crash or tolerance curve in study logs.
Stress Adaptation
Examined for stress-response modulation without ACTH's cortisol effect.
No Sleep Disruption
Daytime administration is not associated with sleep-onset interference in the literature.
Reconstitution
- Commonly supplied as a nasal-spray solution or lyophilized powder
- 30 mg vial + 3 mL bacteriostatic water = 10 mg/mL (approx. 300 mcg per 0.03 mL spray)
- For subcutaneous designs at 10 mg/mL, 1 unit on a U-100 syringe = 100 mcg
Suggested research protocol
- Routes studied: intranasal (most common) and subcutaneous.
- Timing: morning and early afternoon; late dosing is avoided in most designs.
- Cycle: 10–20 day blocks with equivalent breaks, rather than continuous use.
- Refrigerate reconstituted solution.
Dosing Reference
| Phase | Daily amount | Notes |
|---|---|---|
| Introductory | 300 mcg | Single morning administration |
| Standard | 600 mcg | Split morning / early afternoon |
| Extended | 900 mcg | Short blocks only |
Handling & Notes
- Intranasal administration may cause brief irritation; alternate nostrils.
- Cycling is emphasized in the literature more than dose escalation.
- Frequently studied alongside Selank for a combined focus-and-calm profile.
Stack Up
Compounds studied alongside Semax
This guide is provided for informational and research reference only. Semax is intended for laboratory research use exclusively and is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary consumption.